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    • How does nintedanib work?

    Nintedanib is a multi-targeted tyrosine kinase inhibitor (TKI) that works by inhibiting pathways involved in the pathogenesis of ILDs1

    Nintedanib affects the underlying pathways involved in fibrotic tissue remodeling1-4

    MOA
    MOA

    The MOA is based on preclinical data and provided for illustrative purposes only.1

    Nintedanib binds intracellularly to key receptors to block downstream signaling cascades1:

    • PDGFR-α and -β
    • FGFR 1-3
    • VEGFR 1-3

    FGFR, fibroblast growth factor receptor; ILD, interstitial lung disease; MOA, mechanism of action; PDGFR, platelet-derived growth factor receptor; VEGFR, vascular endothelial growth factor receptor.

    References

    1. Richeldi L, Costabel U, Selman M, et al. Efficacy of a tyrosine kinase inhibitor in idiopathic pulmonary fibrosis. N Engl J Med. 2011;365(12):1079-1087.

    2. Hilberg F, et al. Cancer Res. 2008;68(12):4774-4782.

    3. Wollin L, et al. J Pharmacol Exp Ther. 2014;349(2):209-220.

    4. Selman M, et al. Ann Intern Med. 2001;134(2):136-151.